MegaCarti®
MegaCarti® (L&C Bio) is the world’s first human derived medical device designed for knee cartilage regeneration. Formulated as a dense paste mixing human hyaline cartilage particles with a hyaluronic acid hydrogel, it treats severe, full thickness defects (ICRS Grade III/IV, 1.5–10 cm²) in patients aged 19 to 65.
Applied immediately after microfracture surgery often alongside High Tibial Osteotomy (HTO) MegaCarti® acts as a biological scaffold that traps bone marrow stem cells to promote the growth of durable, genuine hyaline cartilage instead of weak fibrous tissue. Gammasterilized and stored at room temperature (1°C–30°C), it eliminates the need for autologous tissue harvesting and is currently expanding across Southeast Asia via CONMED Asia.
MegaShield®
MegaShield® is a highly biocompatible anti-adhesion barrier and dressing medical device developed by L&C Bio, primarily used to reduce tissue adhesions following thyroid surgery. Formulated with a unique blend of acellular dermal matrix (ADM) powder, hyaluronic acid, and a thermosensitive poloxamer, the solution exhibits temperature dependent viscosity. Upon injection into the surgical site, it reacts to body temperature by becoming significantly more viscous, forming an effective physical barrier that safely and efficiently prevents adjacent tissues from adhering to one another during the healing process.
MegaDBM®
MegaDBM® is an advanced medical device developed by L&C Bio, designed as a bone graft biomaterial to treat bone defects caused by injuries or osteoporosis. Its innovative mechanism relies on a sophisticated formulation that blends demineralized bone matrix (DBM) with a biocompatible hyaluronic acid carboxymethylcellulose (HA-CMC) gel carrier. This dynamic combination allows the mixture to effectively fill, stabilize, and replace missing tissue at the site of the bone defect while providing osteoinductive properties to support natural bone regeneration. Approved for clinical use under medical regulations, MegaDBM® serves as a reliable biological implant that should be stored at room temperature (1–30°C) and utilized strictly in accordance with its official instructions and safety precautions.
MegaDBM® S
MegaDBM® S is an advanced, putty type bone graft biomaterial developed by L&C Bio to fill bone defects caused by injury or osteoporosis. It consists of demineralized bone matrix (DBM) and bone mineral powder suspended in a cross linked hyaluronic acid (HA) and carboxymethylcellulose (CMC) gel carrier. This ready to use implant offers high physical integrity, requires no thawing or mixing, and can be easily shaped or injected into the surgical site. With excellent osteoinductive and osteoconductive properties, the gamma sterilized product successfully promotes bone regeneration and tissue integration. It must be stored at room temperature (1~30°C) and is strictly indicated for single patient use by medical professionals.
MegaCartilage-E™
MegaCartilage-E™ is an advanced, sterile biological graft specifically engineered to address extensive or complex cartilage erosion. It serves as an optimized osteochondral scaffold that mimics the native microenvironment of articular cartilage. By facilitating enhanced cell attachment, proliferation, and differentiation of endogenous chondrocytes or mesenchymal stem cells, this product accelerates natural tissue synthesis, restoring joint stability and structural integrity in orthopedic patients.
MegaCure®
MegaCure® is an advanced medical device developed by L&C Bio, classified as an absorbable biological wound dressing (Approval No. 20-819). Formulated as a convenient gel, it features a unique combination of powdered cross linked Acellular Dermal Matrix (ADM) derived from the human body, cross linked hyaluronic acid, and water for injection. When applied directly to an affected area, MegaCure® acts as a highly effective covering material that protects open wounds and maintains an optimal moist healing environment. A key advantage of this innovative product is its user friendly application, as it can be applied seamlessly to the wound without requiring any separate preparation, such as mixing with sterile distilled water or normal saline. MegaCure® is specifically designed for use on various types of unhealed open wounds, including traumatic injuries and chronic ulcers, though it is not intended for treating third degree burns.
MegaNuovo®
MegaNuovo® is an innovative soft tissue graft designed to facilitate complex anatomical repair where structural backing and cell migration are required. It acts as an optimal biological extracellular platform, retaining structural elastin and collagen fibers while remaining free of cellular components. It is highly resistant to enzymatic degradation, ensuring long term tissue support while host fibrovascular tissue slowly integrates and repopulates the graft site.
MegaDerm® Plus
MegaDerm® Plus is a medical device developed by L&C Bio. It is an acellular dermal matrix (ADM) derived from donated human skin in which the epidermis and cellular components are removed, leaving a biological extracellular matrix structure. The material is cross linked and processed into freeze dried forms such as sheets, powders, and rod shaped carving types, allowing it to be adapted for various surgical applications. The product is designed to replace or reconstruct damaged or depressed skin tissue caused by accidents or diseases and provides a scaffold that supports tissue regeneration and integration with the patient’s body. MegaDerm® Plus should be stored at 1-30 °C with a shelf life of about three years, and it must be used only by medical professionals under sterile conditions, following strict safety precautions to prevent infection or adverse reactions.
MegaBone Oss®
MegaBone Oss® is a dental bone graft material designed to repair and regenerate alveolar bone defects. The product is composed of human cortical and cancellous bone powder combined with sodium hyaluronate (hyaluronic acid), which acts as a carrier to help apply the bone particles to the implantation site. Once implanted into the defect area, the material fills and replaces the missing bone and promotes new bone formation. It is intended for use by medical professionals to treat alveolar bone defects in dental procedures. The product should be stored at room temperature (1–30 °C) and has a shelf life of three years from the manufacturing date. Proper sterile handling is required, and it should not be used in patients with allergies to its components, potential adverse reactions, or inflammation at the transplant site.
MegaDerm Ultra® S
MegaDerm Ultra® S is a medical device made from an acellular dermal matrix (ADM) derived from porcine skin. The epidermis, cells, and impurities are removed, and the material undergoes virus inactivation and freeze drying to create a purified collagen-based tissue scaffold. It is designed to support the repair or reconstruction of damaged tissues, particularly ligaments, tendons, and muscles, during internal or surgical treatments. The product should be stored at room temperature (1–30 °C), protected from direct sunlight and high humidity, and has a shelf life of three years from the manufacturing date. It must be used only by medical professionals according to the instructions, and special precautions are required for patients with immune disorders or allergies to porcine-derived materials. The device is sterilized using an electron beam and is intended for single patient use after rehydration before transplantation.
MegaHeal®
MegaHeal® is a medical device designed for scar management. It is a flexible, thin, self-adhesive silicone gel sheet used to protect both old and newly formed scars. The product works by covering and protecting closed scars, helping to manage and improve their condition; however, it should not be applied to open wounds. For proper storage, MegaHeal® should be kept in a cool, dry place below 25°C and protected from direct sunlight, with a shelf life of about five years from the date of manufacture. Users are advised not to apply ointments, creams, or other products together with the silicone sheet because these may reduce its effectiveness or cause skin irritation. If skin problems such as rash, itching, or maceration occur, the use time should be reduced or the product should be discontinued and medical advice should be sought. The product should also not be used by individuals who are allergic to silicone or polysiloxane.
CryoPen®
CryoPen® is a portable cryosurgical medical device designed to destroy unwanted tissue by applying extreme cold. The pen-shaped instrument uses liquefied nitrous oxide (N₂O) gas and sprays it onto the treatment area at approximately −89°C, effectively freezing and destroying targeted cells. It is intended for controlled tissue destruction in medical procedures and must be used by trained medical professionals. The device is typically stored at room temperature with the protective cap closed, and its gas cartridges are recommended for single use. During use, precautions include careful handling, proper cleaning with non-alcohol sterilizing solutions, and avoiding operation in temperatures below 15°C. Possible side effects may include temporary skin pigmentation changes or minor skin damage in delicate areas, though these effects usually disappear after a few months.
Fluobeam®
Fluobeam® is a medical imaging device developed by L&C Bio that uses near infrared (NIR) laser technology to visualize tissue perfusion, blood vessels, lymphatic vessels, and parathyroid glands during medical procedures. The system works by illuminating the target area with near-infrared light through an optical head and detecting fluorescence signals using a CCD camera and specialized filters. These signals can originate from an injected fluorescent dye such as Indocyanine Green (ICG), which circulates through the vascular and lymphatic systems, or from natural autofluorescence emitted by certain tissues such as the parathyroid glands. The device processes these signals and displays real time images, allowing surgeons to observe vascular flow and tissue conditions during surgery. Fluobeam® typically consists of several components including an optical head, control box, panel PC, imaging software, and a mobile cart. It is primarily used as an intraoperative imaging aid to help surgeons assess tissue perfusion, identify lymphatic or vascular structures, and locate parathyroid glands more accurately during surgical procedures.